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KMID : 0604220030100040137
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Korean Journal Investigative Dermatology
2003 Volume.10 No. 4 p.137 ~ p.142
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Epidermal Stem Cells
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Choi Jee-Ho
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Abstract
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The epidermis is believed to contain two types of proliferating cells. One is an epidermal stem cell(ESC) which is self-maintaining/renewing and source of all differentiating cells in the tissue. Another is a transit amplifying cell(TAC) which has a lower capacity for self-renewal and higher probability of undergoing terminal differentiation. Stem cell is an undifferentiated cell that produces 2 types of daughter cells composed of stem cell itself and TAC. TACs arise from stem cells and after one to five rounds of division, all of their daughter cells underwent terminal differentiation. TACs have a high proliferative rate for only a limited period of time and represent the largest group of dividing cells while less than 5-10% of basal cells could be ESCs. Advances now indicate that there are a number of stem cell repositories within the epidermis, two of which, the interfollicular epidermis and the bulge region of the hair follicle. The clinical implications of understanding ESC biology abound. In this review, I will discuss recent advances of ESC study and their clinical application.
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KEYWORD
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Epidermal stem cell(ESC), Transit amplifying cell(TAC)
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